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Chromosomal and subchromosomal anomalies associated to small for gestational age fetuses with no additional structural anomalies
Author(s) -
Peng Ruan,
Zhou Yi,
Xie HongNing,
Lin MeiFang,
Zheng Ju
Publication year - 2017
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5169
Subject(s) - karyotype , fetus , gestational age , obstetrics , medicine , pregnancy , genetics , chromosome , biology , gene
What's already known about this topic? Published studies have shown a 6.8 to 11.4% incremental yield of chromosomal abnormalities over karyotyping in SGA cases combined with structural anomalies or nonstructural anomalies. What does this study add? Our study showed that chromosomal and subchromosomal anomalies occurred in 7.8% (10/128) SGA fetuses with no additional structural anomalies, among which 9 cases could be identified with CMA. Chromosomal and subchromosomal anomalies occurred significantly higher in cases with oligohydraminos and in early onset cases.