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Assessing the cost of implementing the 2011 Society of Obstetricians and Gynecologists of Canada and Canadian College of Medical Genetics practice guidelines on the detection of fetal aneuploidies
Author(s) -
Lilley Margaret,
Hume Stacey,
Karpoff Nina,
Maire Georges,
Taylor Sherry,
Tomaszewski Robert,
Yoshimoto Maisa,
Christian Susan
Publication year - 2017
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5112
Subject(s) - chorionic villus sampling , amniocentesis , medicine , gynecology , aneuploidy , prenatal diagnosis , obstetrics , products of conception , test (biology) , family medicine , pregnancy , genetics , chromosome , biology , fetus , gestation , paleontology , gene
Background The Society of Obstetricians and Gynecologists of Canada and the Canadian College of Medical Genetics published guidelines, in 2011, recommending replacement of karyotype with quantitative fluorescent polymerase chain reaction when prenatal testing is performed because of an increased risk of a common aneuploidy. Study Objective This study's objective is to perform a cost analysis following the implementation of quantitative fluorescent polymerase chain reaction as a stand‐alone test. Results A total of 658 samples were received between 1 April 2014 and 31 August 2015: 576 amniocentesis samples and 82 chorionic villi sampling. A chromosome abnormality was identified in 14% (93/658) of the prenatal samples tested. The implementation of the 2011 Society of Obstetricians and Gynecologists of Canada and the Canadian College of Medical Genetics guidelines in Edmonton and Northern Alberta resulted in a cost savings of $46 295.80. The replacement of karyotype with chromosomal microarray for some indications would be associated with additional costs. Conclusion The implementation of new test methods may provide cost savings or added costs. Cost analysis is important to consider during the implementation of new guidelines or technologies. © 2017 John Wiley & Sons, Ltd.