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The length of Y‐chromosomal sequence reads in noninvasive prenatal testing reflect allogeneic bone marrow transplant
Author(s) -
BalslevHarder Marie,
Jørgensen Finn Stener,
Kjaergaard Susanne,
Johansen Peter
Publication year - 2017
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5081
Subject(s) - bone marrow transplantation , fetus , bone marrow transplant , bone marrow , medicine , obstetrics , biology , pathology , pregnancy , genetics
What's already known about this topic? NIPT for fetal sex determination is routinely performed, yet false results may arise due to rare incidents such as feto‐placental mosaicism, vanishing twin, or maternal bone marrow transplantation.What does this study adds? We present a statistical method to determine whether the Y‐chromosomal sequences originate from a placental or maternal source, hence eliminating the rare false fetal sex results due to maternal male bone marrow transplants.

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