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Outcome of isolated enlarged cisterna magna identified in utero: experience at a single medical center in mainland China
Author(s) -
Liu Zequn,
Han Jin,
Fu Fang,
Liu Juan,
Li Ru,
Yang Xin,
Pan Min,
Zhen Li,
Li Dongzhi,
Liao Can
Publication year - 2017
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5046
Subject(s) - fetus , in utero , cisterna magna , medicine , prenatal diagnosis , magnetic resonance imaging , pediatrics , gross motor skill , obstetrics , pregnancy , biology , radiology , motor skill , cerebrospinal fluid , genetics , psychiatry
Objective The objective of this study is to explore the effects of prenatal isolated enlarged cisterna magna (IECM) on postnatal development. Methods We followed up 123 fetuses with an enlarged cisterna magna (ECM), who were divided into IECM (group 1) and non‐IECM (ECM plus other anomalies, group 2) groups, and compared 60 normal infants with normal fetal ultrasound. We assessed infants postnatally using the Gesell Developmental Schedules. Fetal magnetic resonance imaging, karyotyping, and chromosomal microarray analysis test were offered. Results The developmental quotients of gross motor and adapting abilities were significantly lower in infants with IECM compared with normal infants (80.81 ± 3.44 vs 99.20 ± 4.54 and 98.70 ± 3.27 vs 100.30 ± 5.33, respectively), and the depths ≥15 mm and 13 to 14.90 mm were associated with significantly lower adapting abilities ( P < 0.03 and P < 0.05) compared with the normal (97.16 ± 2.17 and 98.21 ± 1.76 vs 100.30 ± 5.33, respectively), while these scores were still within the borderline range, and the other subtests were not significantly different. Furthermore, the group 2 showed a significantly worse performance in the test. Conclusions The outcome of children with IECM may be guarded, especially some subtle deficits in adapting and gross motor abilities. In contrast, the developmental quotients of infants with prenatal non‐IECM were lower than that those of normal infants. © 2017 John Wiley & Sons, Ltd.