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Premium Outcome of isolated enlarged cisterna magna identified in utero: experience at a single medical center in mainland China
Author(s)
Liu Zequn,
Han Jin,
Fu Fang,
Liu Juan,
Li Ru,
Yang Xin,
Pan Min,
Zhen Li,
Li Dongzhi,
Liao Can
Publication year2017
Publication title
prenatal diagnosis
Resource typeJournals
PublisherWiley-Blackwell
Abstract Objective The objective of this study is to explore the effects of prenatal isolated enlarged cisterna magna (IECM) on postnatal development. Methods We followed up 123 fetuses with an enlarged cisterna magna (ECM), who were divided into IECM (group 1) and non‐IECM (ECM plus other anomalies, group 2) groups, and compared 60 normal infants with normal fetal ultrasound. We assessed infants postnatally using the Gesell Developmental Schedules. Fetal magnetic resonance imaging, karyotyping, and chromosomal microarray analysis test were offered. Results The developmental quotients of gross motor and adapting abilities were significantly lower in infants with IECM compared with normal infants (80.81 ± 3.44 vs 99.20 ± 4.54 and 98.70 ± 3.27 vs 100.30 ± 5.33, respectively), and the depths ≥15 mm and 13 to 14.90 mm were associated with significantly lower adapting abilities ( P  < 0.03 and P  < 0.05) compared with the normal (97.16 ± 2.17 and 98.21 ± 1.76 vs 100.30 ± 5.33, respectively), while these scores were still within the borderline range, and the other subtests were not significantly different. Furthermore, the group 2 showed a significantly worse performance in the test. Conclusions The outcome of children with IECM may be guarded, especially some subtle deficits in adapting and gross motor abilities. In contrast, the developmental quotients of infants with prenatal non‐IECM were lower than that those of normal infants. © 2017 John Wiley & Sons, Ltd.
Subject(s)anatomy , biology , cerebrospinal fluid , cisterna magna , cognition , fetus , genetics , gross motor skill , in utero , intelligence quotient , medicine , motor skill , obstetrics , pediatrics , pregnancy , prenatal diagnosis , psychiatry
Language(s)English
SCImago Journal Rank0.956
H-Index97
eISSN1097-0223
pISSN0197-3851
DOI10.1002/pd.5046

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