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Role of fetal MRI in the evaluation of isolated and non‐isolated corpus callosum dysgenesis: results of a cross‐sectional study
Author(s) -
Manganaro Lucia,
Bernardo Silvia,
De Vito Corrado,
Antonelli Amanda,
Marchionni Enrica,
Vinci Valeria,
Saldari Matteo,
Di Meglio Letizia,
Giancotti Antonella,
Silvestri Evelina,
Catalano Carlo,
Pizzuti Antonio
Publication year - 2017
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4990
Subject(s) - polymicrogyria , dysgenesis , corpus callosum , agenesis of the corpus callosum , ventriculomegaly , medicine , agenesis , cortical dysplasia , magnetic resonance imaging , hypoplasia , lissencephaly , odds ratio , anatomy , fetus , pathology , pregnancy , radiology , biology , biochemistry , genetics , gene
Purpose The aims of this study were to characterize isolated and non‐isolated forms of corpus callosum dysgenesis (CCD) at fetal magnetic resonance imaging (MRI) and to identify early predictors of associated anomalies. Methods We retrospectively analyzed 104 fetuses with CCD undergoing MRI between 2006 and 2016. Corpus callosum, cavum septi pellucidi, biometry, presence of ventriculomegaly, gyration anomalies, cranio‐encephalic abnormalities and body malformations were evaluated. Results of genetic tests were also recorded. Results At MRI, isolated CCD was 26.9%, the rest being associated to other abnormalities. In the isolated group, median gestational age at MRI was lower in complete agenesis than in hypoplasia (22 vs 28 weeks). In the group with additional findings, cortical dysplasia was the most frequently associated feature ( P = 0.008), with a more frequent occurrence in complete agenesis (70%) versus other forms; mesial frontal lobes were more often involved than other cortical regions ( P = 0.006), with polymicrogyria as the most frequent cortical malformation (40%). Multivariate analysis confirmed the association between complete agenesis and cortical dysplasia (odds ratio = 7.29, 95% confidence interval 1.51–35.21). Conclusions CCD is often complicated by other intra‐cranial and extra‐cranial findings (cortical dysplasias as the most prevalent) that significantly affect the postnatal prognosis. The present study showed CCD with associated anomalies as more frequent than isolated (73.1%). In isolated forms, severe ventriculomegaly was a reliable herald of future appearance of associated features. © 2016 John Wiley & Sons, Ltd.