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Gender impact on first trimester markers in Down syndrome screening
Author(s) -
Larsen Severin Olesen,
Wøjdemann Karen R.,
Shalmi AnneCathrine,
Sundberg Karin,
Christiansen Michael,
Tabor Ann
Publication year - 2002
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.493
Subject(s) - pregnancy associated plasma protein a , crown rump length , fetus , medicine , down syndrome , gestational age , nuchal translucency , obstetrics , aneuploidy , pregnancy , trisomy , alpha fetoprotein , gestation , gynecology , first trimester , biology , psychiatry , gene , hepatocellular carcinoma , chromosome , genetics , biochemistry
Abstract The influence of fetal gender on the level in the first trimester of the serological markers alpha‐fetoprotein (AFP), pregnancy‐associated plasma protein‐A (PAPP‐A) and free beta human chorionic gonadotropin (βhCG) and on nuchal translucency is described for 2637 singleton pregnancies with normal outcome. Mean log MoM values for pregnancies with female and male fetuses were calculated using regression of log marker values on gestational age expressed as crown rump length and on maternal weight. A pronounced gender impact was found for free βhCG, being 16% higher for female than for male fetuses. Copyright © 2002 John Wiley & Sons, Ltd.