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Observations of fetal brain activity via non‐invasive magnetoencephalography following administration of magnesium sulfate for neuroprotection in preterm labor
Author(s) -
EscalonaVargas Diana I.,
Thagard Andrew S.,
McGrail Kaitlin,
Napolitano Peter G.,
Magann Everett F.,
Lowery Curtis L.,
Eswaran Hari
Publication year - 2016
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4919
Subject(s) - neuroprotection , magnesium , medicine , fetus , offspring , excitatory postsynaptic potential , cerebral palsy , anesthesia , pregnancy , pharmacology , chemistry , biology , inhibitory postsynaptic potential , organic chemistry , psychiatry , genetics
What's Already Known About This Topic? Magnesium sulfate is administered to women at risk for delivering preterm to reduce the incidence of cerebral palsy in their offspring. The mechanism by which magnesium sulfate provides ‘neuroprotection’ is unclear, although it may work in part by preventing excitatory injury to neurons. What Does This Study Add? This study demonstrates that most human fetuses exposed to magnesium sulfate demonstrated a decrease in overall brain activity. Additional research is needed to correlate this reduction with excitatory neurotransmission.