Premium
Maternal vitamin B12 deficiency and abnormal cell‐free DNA results in pregnancy
Author(s) -
SchuringBlom Heleen,
Lichtenbelt Klaske,
Galen Karin,
Elferink Martin,
Weiss Marjan,
Vermeesch Joris Robert,
PageChristiaens Lieve
Publication year - 2016
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4863
Subject(s) - cell free fetal dna , pregnancy , vitamin b12 , hemolysis , prenatal diagnosis , genetic testing , medicine , dna , genetics , biology , immunology , fetus
What's Already Known about this Topic? Prenatal testing with cell‐free DNA may incidentally identify maternal genetic anomalies and malignancies.What does this Study Add? Profound vitamin B12 deficiency with intramedullary hemolysis may cause abnormal genomic patterns that can be detected by cell‐free DNA sequencing.