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Adverse perinatal outcomes are more frequent in pregnancies with a low fetal fraction result on noninvasive prenatal testing
Author(s) -
Krishna Iris,
Badell Martina,
Loucks Tammy L.,
Lindsay Michael,
Samuel Amber
Publication year - 2016
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4779
Subject(s) - medicine , obstetrics , pregnancy , placental abruption , miscarriage , odds ratio , fetus , gestational age , confidence interval , low birth weight , body mass index , genetics , biology
Objective This study aimed to assess risk of an adverse perinatal outcome for women with a low fetal fraction (LFF) result on noninvasive prenatal testing (NIPT). Study Design A retrospective cohort study whereby women with an LFF result were compared with women who had a sufficient fetal fraction (SFF) result on NIPT. Inclusion criteria were singleton pregnancies with quantification of fetal fraction and pregnancy outcome information. Primary outcome was a composite of any of the following: miscarriage, fetal demise, neonatal death, preterm birth, pregnancy‐associated hypertensive disorder, placental abruption, and low birth weight. Results Three hundred forty‐eight (94%) women had an SFF result, and 22 (6%) women had an LFF result. The mean gestational age at the time of NIPT was comparable for both groups. Women with an LFF result were more likely to be African American (86% vs 52%; p = 0.007) and have a higher body mass index (BMI) (mean BMI = 37 kg/m 2 vs BMI = 29 kg/m 2 ; p ≤ 0.001) than women with an SFF result. The composite outcome was significantly more common in the LFF group (59.1% vs 29%; p = 0.003). After adjusting for race and BMI, LFF remained independently associated with adverse perinatal outcome with adjusted odds ratio = 2.5 (95% confidence interval 1.01–6.2; p = 0.049). Conclusions Women with an LFF result have an increased likelihood of an adverse pregnancy outcome. © 2016 John Wiley & Sons, Ltd.