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Screening performances of abnormal first‐trimester ductus venosus blood flow and increased nuchal translucency thickness in detection of major heart defects
Author(s) -
KaradzovOrlic Natasa,
Egic Amira,
Filimonovic Dejan,
DamnjanovicPazin Barbara,
Milovanovic Zagorka,
Lukic Relja,
Mandic Vesna,
Joksic Ivana,
Vukomanovic Vladimir,
Kosutic Jovan,
Djuricic Slavisa,
Mikovic Zeljko
Publication year - 2015
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4693
Subject(s) - ductus venosus , medicine , fetus , gestational age , blood flow , nuchal translucency measurement , cardiology , population , nuchal translucency , percentile , first trimester , pregnancy , biology , statistics , genetics , environmental health , mathematics
Objective The aim of this study was to evaluate the screening performances of abnormal ductus venosus (DV) blood flow for the detection of heart defects in chromosomally normal fetuses with increased nuchal translucency (NT) thickness at 11–13 + 6 weeks' gestational in a population of singleton pregnancies. Methods During an 8‐year period, all singleton pregnancies from 11 + 0 to 13 + 6 weeks were scanned for NT and DV blood flow assessment. Two groups of cases with abnormal NT were evaluated: NT ≥ 95th and NT ≥ 99th centile. DV waveforms were considered to be abnormal if the a‐wave was reversed or absent (R/A). Results Addition of DV R/A a‐wave to either NT ≥ 95th or NT ≥ 99th percentile increased specificity ( p < 0.001 and p < 0.001, respectively), but not screening performances in detection of major heart defects ( p = 0.73 and p = 0.91, respectively). Combination of DV R/A a‐wave with NT ≥ 95th or NT ≥ 99th centile correlated with right heart defects ( p = 0.024 and p = 0.013, respectively). Conclusions In chromosomally normal fetuses, addition of abnormal DV a‐wave to increased NT does not improve screening performances of NT in detection of major hearts defects in first trimester. However, there is correlation of such parameter with right heart defects and AV septal defects. © 2015 John Wiley & Sons, Ltd.