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First trimester placental volume and vascular indices in pregnancies complicated by preeclampsia
Author(s) -
Plasencia Walter,
GonzálezDávila Enrique,
González Lorenzo Alejandra,
ArmasGonzález Marina,
Padrón Erika,
GonzálezGonzález Nieves L.
Publication year - 2015
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4692
Subject(s) - medicine , eclampsia , obstetrics , preeclampsia , pregnancy , prospective cohort study , gestational age , birth weight , placenta , gestation , gynecology , fetus , biology , genetics
Objective To analyze placental volume and vascularization at first trimester in women with pre‐eclampsia, and secondarily, the effect of maternal characteristics on placental development and perinatal outcomes. Methods This was a prospective cohort study including women seen between 11 and 14 weeks of pregnancy. Biophysical and biochemical markers included in the screening program for aneuploidy were recorded. Placental volume and vascularization indices were obtained using three‐dimensional power‐Doppler imaging and Virtual Organ Computer‐aided Analysis (VOCAL) techniques. Results We compared 84 women with pre‐eclampsia versus 904 non‐affected. Placental volume and all vascular indices were lower in those with pre‐eclampsia. Multivariate analysis showed that parity and maternal weight had a significant effect on placental volume and vascularization indices ( p = 0.004 and p = 0.011). In women with pre‐eclampsia, multiparity showed a negative effect on placental volume, gestational age, birth weight and Apgar test score. By contrast, in the non‐affected group, multiparity had a protective effect. Low maternal weight had a significantly worse effect on placental vascularization and perinatal outcomes in women with pre‐eclampsia. Conclusions Women with pre‐eclampsia showed significantly lower placental volume and vascularization indices at first trimester. Multiparity and low maternal weight independently exacerbated the negative effects of pre‐eclampsia on placental characteristics and perinatal outcomes. © 2015 John Wiley & Sons, Ltd.