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First trimester ultrasound screening for Down syndrome based on maternal age, fetal nuchal translucency and different combinations of the additional markers nasal bone, tricuspid and ductus venosus flow
Author(s) -
Abele Harald,
Wagner Philipp,
Sonek Jiri,
Hoopmann Markus,
Brucker Sara,
ArtuncUlkumen Burcu,
Kagan Karl Oliver
Publication year - 2015
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4664
Subject(s) - ductus venosus , medicine , nasal bone , trisomy , fetus , nuchal translucency measurement , down syndrome , obstetrics , aneuploidy , ultrasound , nuchal translucency , crown rump length , chorionic villus sampling , pregnancy , prenatal diagnosis , first trimester , radiology , surgery , biology , chromosome , biochemistry , genetics , psychiatry , gene
What's already known about this topic? First trimester screening for Down syndrome based on maternal age and fetal NT detects about 70% of affected fetuses for a 3% false positive rate.What does this study add? The assessment of one, two and three of the additional ultrasound markers nasal bone, tricuspid and ductus venosus flow increases the detection rate to about 80%, 87% and 94%, respectively, for the same false positive rate. © 2015 John Wiley & Sons, Ltd.