Prenasal thickness to nasal bone length ratio in normal and trisomy 21 fetuses at 11–14 weeks of gestation | Zendy

ManegoldBrauer Gwendolin | Zendy; Bourdil Lucas | Zendy; Berg Christoph | Zendy; Schoetzau Andreas | Zendy; Gembruch Ulrich | Zendy; Geipel Annegret | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Prenasal thickness to nasal bone length ratio in normal and trisomy 21 fetuses at 11–14 weeks of gestation

Author(s) -

ManegoldBrauer Gwendolin,

Bourdil Lucas,

Berg Christoph,

Schoetzau Andreas,

Gembruch Ulrich,

Geipel Annegret

Publication year - 2015

Publication title -

prenatal diagnosis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.956

H-Index - 97

eISSN - 1097-0223

pISSN - 0197-3851

DOI - 10.1002/pd.4649

Subject(s) - trisomy , fetus , medicine , gestational age , nasal bone , gestation , aneuploidy , nuclear medicine , pregnancy , gynecology , anatomy , biology , biochemistry , genetics , gene , chromosome

What's already known about this topic? The prenasal thickness (PT) to nasal bone length (NBL) ratio is a strong marker for trisomy 21 fetuses in the second trimester, and preliminary data from the first trimester in 9 fetuses with trisomy 21 showed an increased PT What does this study add? A reference range for PT/NBL ratio in 1000 normal fetuses compared to 44 fetuses with trisomy 21. A cut‐off value of 0.8 showed a sensitivity of 86.4% and a specificity of 98.4% for trisomy 21. PT/NBL between 11 and 14 gestational weeks is feasible with high intraclass correlation. © 2015 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research