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Uterine leiomyoma confounding a noninvasive prenatal test result
Author(s) -
Dharajiya Nilesh G.,
Namba Akira,
Horiuchi Isao,
Miyai Shunsuke,
Farkas Daniel H.,
Almasri Eyad,
Saldivar JuanSebastian,
Takagi Kenjiro,
Kamei Yoshimasa
Publication year - 2015
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4629
Subject(s) - confounding , medicine , obstetrics , prenatal diagnosis , fetus , pregnancy , leiomyoma , diagnostic test , gynecology , pathology , pediatrics , genetics , biology
What's already known about this topic? The noninvasive prenatal testing from maternal blood can be confounded by maternal conditions that lead to structural variants/copy number variations in the genome.What does this study add? This study provides further evidence that the grossly ‘abnormal’ and ‘non‐reportable’ noninvasive prenatal testing result due to global genomic changes was attributable to a maternal uterine leiomyoma, in an otherwise normal fetus. The possibility of such adventitious findings is something about which physicians ordering noninvasive prenatal testing for their patients may want to offer pre‐test counseling. © 2015 John Wiley & Sons, Ltd.