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Diagnostic value of ultrasonographic combining biochemical markers for Down syndrome screening in first trimester: a meta‐analysis
Author(s) -
Liu Yang,
Ye Xingguang,
Zhang Na.,
Zhang Baohuan,
Guo Congcong,
Huang Weihuang,
Jing Lipeng,
Wang Man,
Yang Guang,
Wei Xiangcai,
Jing Chunxia
Publication year - 2015
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4626
Subject(s) - diagnostic odds ratio , meta analysis , likelihood ratios in diagnostic testing , medicine , down syndrome , bivariate analysis , receiver operating characteristic , odds ratio , confidence interval , gynecology , statistics , mathematics , psychiatry
What's already known about this topic? Different combinations of MA and NT and NB and free β‐hCG and PAPP‐A have been used in the first trimester to screen for Down syndrome; however, the sensitivity and specificity of these screening tests varied among studies.What does this study add? This is the first meta‐analysis that analyzes the diagnostic value of four different combining tests by MA and NT and NB and PAPP‐A and free β‐hCG for Down syndrome. It shows that the combination of NT and PAPP and free β‐hCG is a cost‐effective diagnostic tool for Down syndrome. © 2015 John Wiley & Sons, Ltd.