Premium
Second trimester maternal serum alpha‐fetoprotein (MSAFP) as predictor of fetal hemoglobin Bart's disease
Author(s) -
Tongprasert Fuanglada,
Srisupundit Kasemsri,
Luewan Suchaya,
Tongsong Theera
Publication year - 2014
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4465
Subject(s) - medicine , fetus , obstetrics , cutoff , prenatal diagnosis , receiver operating characteristic , pregnancy , biology , genetics , physics , quantum mechanics
What's already known about this topic? Maternal serum alpha‐fetoprotein is produced from the fetal hematopoietic organs, including the yolk sac and fetal liver, and enters maternal circulation by placental transfer. Maternal serum alpha‐fetoprotein is elevated in pregnancies with fetal anemia from different causes.What does this study add? Maternal serum alpha‐fetoprotein is relatively effective in the prediction of fetal Hb Bart's disease, with a level >1.50 MoM having a detection rate of 87%. A higher detection rate can be achieved when maternal serum alpha‐fetoprotein is used in combination with sonographic markers.