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Nitric oxide and reactive species are modulated in the polyphenol‐induced ductus arteriosus constriction in pregnant sheep
Author(s) -
Bubols Guilherme B.,
Zielinsky Paulo,
Piccoli Antônio L.,
Nicoloso Luiz H.,
Vian Izabele,
Moro Angela M.,
Charão Mariele F.,
Brucker Natália,
Bulcão Rachel P.,
Nascimento Sabri.,
Baierle Marília,
Alievi Marcelo M.,
Moresco Rafael N.,
Markoski Melissa,
Garcia Solange C.
Publication year - 2014
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4463
Subject(s) - ductus arteriosus , constriction , nitric oxide , fetus , medicine , catalase , endocrinology , polyphenol , glutathione peroxidase , oxidative stress , glutathione , excretion , chemistry , antioxidant , biochemistry , pregnancy , biology , enzyme , genetics
What's already known about this topic? Polyphenol‐rich foods have been associated to premature ductal constriction when consumed in the third trimester of pregnancy.What does this study add? Polyphenols revealed to induce vasoconstriction of the ductus arteriosus by inhibiting nitric oxide vasodilatation. Consumption of polyphenol‐rich foods in late pregnancy showed partial antioxidant effect by contributing to reduce lipid peroxidation. In contrast, NO‐mediated ductal vasoconstriction could also be associated to oxidative damage to proteins.