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Myo‐inositol in Down syndrome amniotic fluid. A case‐control study
Author(s) -
Santamaria Angelo,
Corrado Francesco,
Interdonato Maria Lieta,
Baviera Giovanni,
Carlomagno Gianfranco,
Cavalli Pietro,
Unfer Vittorio,
D'Anna Rosario
Publication year - 2014
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4398
Subject(s) - inositol , amniotic fluid , down syndrome , second trimester , medicine , fetus , pregnancy , metabolic syndrome , obstetrics , physiology , endocrinology , biology , diabetes mellitus , genetics , receptor , psychiatry
What's already known about this topic? Myo‐inositol is involved in metabolic changes that characterize Down syndrome What does this study add? This study shows that Down syndrome metabolic changes occur very early in the fetal life, with amniotic fluid myo‐inositol concentrations increasing since the mid‐trimester. A possible clinical use of this finding maybe interesting.