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First‐trimester maternal factors and biomarker screening for preeclampsia
Author(s) -
Poon Leona C.,
Nicolaides Kypros H.
Publication year - 2014
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4397
Subject(s) - preeclampsia , medicine , obstetrics , pregnancy , gestation , incidence (geometry) , biomarker , uterine artery , risk factor , gynecology , biology , biochemistry , genetics , physics , optics
Preeclampsia (PE), which affects about 2% of pregnancies, is a major cause of maternal and perinatal morbidity and mortality. PE can be subdivided into early onset PE with delivery <34 weeks' gestation and late onset PE with delivery ≥34 weeks. Early onset PE is associated with a higher incidence of adverse outcome. This review illustrates that effective screening for the development of early onset PE can be provided in the first‐trimester of pregnancy. Screening by a combination of maternal risk factors, mean arterial pressure, uterine artery Doppler, maternal serum pregnancy‐associated plasma protein‐A and placental growth factor can identify about 95% of cases of early onset PE for a false‐positive rate of 10%. © 2014 John Wiley & Sons, Ltd.