Premium
Awareness and motives for use and non‐use of preimplantation genetic diagnosis in familial amyloid polyneuropathy mutation carriers
Author(s) -
Valdrez Kátia,
Silva Susana,
Coelho Teresa,
Alves Elisabete
Publication year - 2014
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4388
Subject(s) - medicine , odds ratio , confidence interval , polyneuropathy , socioeconomic status , logistic regression , demography , pediatrics , environmental health , population , sociology
Objective To assess awareness of preimplantation genetic diagnosis (PGD) and to identify the reasons surrounding its use and non‐use by familial amyloidotic polyneuropathy (FAP) carriers. Method Between January and May 2013, a self‐administered questionnaire was applied to a representative sample of Portuguese FAP carriers, aged between 18 and 55 years and followed at the Northern surveillance unit. Odds ratios (OR) and respective 95% confidence intervals (95% CI) were estimated using multivariate logistic regression. Results Those who reported being aware of PGD (75.4%) were younger (age ≥ 35 years: OR = 0.51; 95% CI 0.26–1.01), had higher household income (>€1000/month: OR = 2.18; 95% CI 1.14–4.14), and were less likely to have children (OR = 0.35; 95% CI 0.16–0.76) and to have an individual diagnosis after 2001 (OR = 0.40; 95% CI 0.20–0.80). The main reasons for use of PGD were to avoid offspring suffering (48.9%), more frequently reported by men, more educated and wealthier, and the ability to raise a healthy child (39.4%). The main reasons for non‐use of PGD were financial costs (29.6%), technical distrust (29.1%), and the time to get pregnant (17.3%). Conclusion The results reveal the importance of cognitive dimensions and mutation carriers' socioeconomic position in the assessment of PGD, highlighting the need to disseminate accurate information and improve accessibility to this technique. © 2014 John Wiley & Sons, Ltd.