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Concordance between prenatal ultrasound and autopsy findings in a tertiary center
Author(s) -
Rodriguez M. Angeles,
Prats Pilar,
Rodríguez Ignacio,
Cusí Victoria,
Comas Carmina
Publication year - 2014
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4368
Subject(s) - concordance , autopsy , medicine , gestational age , pregnancy , obstetrics , pediatrics , fetus , surgery , pathology , biology , genetics
Objective The aim of this study was to evaluate the ultrasound (US)/autopsy concordance in elective termination of pregnancies (TOP) due to fetal causes. Methods We performed a retrospective evaluation of elective TOP from 2004 to 2012. Inclusion criteria were gestational age at termination <24 weeks, fetal pathology and availability of US/autopsy data. Based on the US–autopsy concordance, cases were divided into four groups: Group 1 : agreement; Group 2 : autopsy confirmed all US findings but provided additional information; Group 3 : autopsy didn't confirm all US findings; Group 4 : disagreement. Results One hundred and fifty‐one patients fulfilled the inclusion criteria during the study period. Central nervous system malformations (91.5%), cardiovascular anomalies (90.2%) and renal system malformations (91.3%) were confirmed by autopsy. We found less concordance in the abdominal and musculoskeletal anomalies (61.5% and 66.7%, respectively). There were 130 (86%) fetuses in group 1 , 7 in group 2 (4.6%), 3 in group 3 (1.9%) and 11 in group 4 (7.2%). In 5.29% of cases, the autopsy added relevant information to the diagnosis and counselling. Conclusions Diagnosis concordance between US and necropsy is achieved in almost 90% of cases. An autopsy may help to adjust the diagnosis and help in counselling the parents for a future pregnancy. © 2014 John Wiley & Sons, Ltd.