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Induction of labor compared to dilation and evacuation for postmortem analysis
Author(s) -
Lal A. K.,
Kominiarek M. A.,
Sprawka N. M.
Publication year - 2014
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4346
Subject(s) - autopsy , cytogenetics , medicine , gestational age , significant difference , retrospective cohort study , gynecology , surgery , obstetrics , pregnancy , chromosome , biology , genetics , gene , biochemistry
Objective This study aimed to evaluate the ability to obtain autopsy and cytogenetics after midtrimester termination. Methods A retrospective cohort study of women undergoing termination, via induction or dilation and evacuation (D&E), at 16 0/7–23 6/7 weeks was performed. Exclusion criteria were elective termination, preterm labor, PPROM, and no autopsy or cytogenetic exam performed. The ability to obtain cytogenetics and autopsy as well as complications rates were compared between the two groups with Chi‐square tests. Results Of the 469 women who met the inclusion criteria, 158 had an induction and 312 had a D&E. The induction of labor group had higher mean gestational ages, p < 0.01. Successful autopsy was more likely in the induction group, 94.3%, versus D&E group, 34.7%, p = 0.01. There was no difference in ability to obtain cytogenetics between the two groups, 89.1% in the induction group, and 92.3% in D&E group, p = 0.4. There was a difference in the total complication rates between the groups, 9.8% (26) in the induction versus 6.4% (20) in the D&E group, p < 0.01; however, there was no difference in major complications. Conclusions Midtrimester terminations by induction were more likely to have successful autopsies when compared with D&E. The ability to obtain cytogenetics was similar regardless of termination mode. © 2014 John Wiley & Sons, Ltd.