Premium
Long‐term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia: a review
Author(s) -
Lindenburg Irene T. M.,
Klink Jeanine M.,
SmitsWintjens Vivianne E. H. J.,
Kamp Inge L.,
Oepkes Dick,
Lopriore Enrico
Publication year - 2013
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4152
Subject(s) - medicine , polycythaemia , pediatrics , parvovirus , pregnancy , fetus , obstetrics , intensive care medicine , immunology , virus , biology , genetics
Perinatal survival rates after intrauterine transfusions (IUT) for red cell alloimmunisation now exceed 90%, which demonstrates the safety and efficacy of one of the most successful procedures in fetal therapy. However, improved perinatal survival could lead to an increased number of children with long‐term disabilities. The importance of long‐term follow‐up studies in fetal therapy lies in both the necessity of evaluation of antenatal management as well as in evidence‐based preconceptional and prenatal counselling. This review describes the possible long‐term cardiovascular and neurodevelopmental sequelae after IUT treatment for different indications including red cell alloimmunisation, parvovirus B19 infection, fetomaternal haemorrhage and twin anaemia‐polycythaemia sequence. © 2013 John Wiley & Sons, Ltd.