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Uptake of noninvasive prenatal testing (NIPT) in women following positive aneuploidy screening
Author(s) -
Chetty Shilpa,
Garabedian Matthew J.,
Norton Mary E.
Publication year - 2013
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.4125
Subject(s) - medicine , logistic regression , obstetrics , prenatal screening , gynecology , prenatal diagnosis , advanced maternal age , genetic testing , pregnancy , fetus , biology , genetics
Objective The aim of this study was to investigate how the introduction of noninvasive prenatal testing (NIPT) impacted women's testing choices following a positive prenatal screening (PNS) result. Methods Beginning in March 2012, women referred to our Prenatal Diagnosis Center following a positive PNS result were offered NIPT or invasive prenatal diagnosis. Rates of invasive testing and declining follow‐up were compared with testing decisions the prior year. Differences were compared using t ‐test and chi‐square. Multivariable logistic regression was performed to identify predictors of test choice. Results Between March 2012 and February 2013, 398 screen positive women were seen: 156 (39.2%) underwent invasive testing, 157 (39.4%) had NIPT and 84 (21.1%) declined further testing. In the prior year, 638 screen positive patients were seen: 301 (47.2%) had invasive testing and 337 (52.8%) declined. The rate of invasive testing declined significantly ( p = 0.012). Moreover, fewer women declined follow‐up testing after introduction of NIPT, 21.2% versus 52.8%, p ≤ 0.001. Race/ethnicity and timing of results (first versus second trimester) were predictors of testing choices; payer and maternal age were not. Conclusion The introduction of NIPT resulted in a significant decrease in invasive diagnostic testing. Additionally, fewer women declined further testing when NIPT was available. © 2013 John Wiley & Sons, Ltd.