Premium
Reference ranges for time‐related analysis of ductus venosus flow velocity waveforms in singleton pregnancies
Author(s) -
Nakagawa Kayoko,
Tachibana Daisuke,
Nobeyama Hiroyuki,
Fukui Mitsuru,
Sumi Toshiyuki,
Koyama Masayasu,
Ishiko Osamu,
Hecher Kurt
Publication year - 2012
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.3908
Subject(s) - ductus venosus , gestational age , cardiology , medicine , fetus , diastole , tricuspid valve , heart rate , gestation , pregnancy , blood pressure , biology , genetics
Objectives To investigate time intervals of ductus venosus (DV) flow velocity waveforms (FVW) in correlation to fetal heart rate and gestational age and to construct reference ranges for the second and third trimester. Furthermore, we investigate time intervals of FVW through the tricuspid valve. Methods Flow velocity waveforms of the DV and through the tricuspid valve were recorded in 135 normal singleton fetuses between 17 and 38 weeks' gestation. Time intervals for systolic (S) and early diastolic (D) peaks were analyzed regarding acceleration time (acc‐S for S, acc‐D for D) and deceleration time (dec‐S for S, dec‐D for D), respectively. Similarly, time intervals for both peaks of right ventricular inflow were analyzed regarding acceleration time (acc‐E for E‐wave, acc‐A for A‐wave) and deceleration time (dec‐E for E‐wave, dec‐A for A‐wave), respectively. Results In the DV, acc‐D and dec‐D increased significantly with gestational age. In tricuspid valve, acc‐E and acc‐A showed a significant increase with gestational age. All parameters except acc‐S showed significant negative correlations with fetal heart rate. Conclusion With advancing gestational age, prolongation of the diastolic phase of DV‐FVW and of the E‐wave of tricuspid flow was observed, suggesting maturation of ventricular diastolic function. Time‐related analysis of Doppler signals of DV‐FVW may provide detailed insights into fetal cardiac function. © 2012 John Wiley & Sons, Ltd.