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Long‐term follow‐up of infants after transcervical chorionic villus sampling and after amniocentesis to compare congenital abnormalities and health status
Author(s) -
Schaap Arty H. P.,
van der Pol Hans G.,
Boer Kees,
Leschot Nico J.,
Wolf Hans
Publication year - 2002
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.371
Subject(s) - medicine , amniocentesis , chorionic villus sampling , pediatrics , respiratory distress , pregnancy , congenital malformations , gestational age , gestation , obstetrics , prenatal diagnosis , fetus , surgery , genetics , biology
Objectives Next to procedure‐related fetal loss, other adverse effects of invasive prenatal diagnosis have been reported: limb defects after chorionic villus sampling (CVS) or early amniocentesis and respiratory distress after amniocentesis (AC). Because minor abnormalities may be overlooked in routine follow‐up, we obtained long‐term follow‐up data after CVS and AC. Methods 1509 women with a singleton pregnancy who had transcervical CVS were matched by age and season of conception with 1509 women with singleton pregnancies who had AC. All procedures were performed during 1985–1991 for advanced maternal age >35 years. Data regarding congenital malformations (classified according Eurocat), neonatal and paediatric morbidity and complications of motor development, speech, hearing and visual function were obtained by questionnaire in 1993–1995. Results Short‐term outcome was known in all but ten infants. Questionnaires with a structured design were mailed to all women with a surviving infant ( n =2810); 86.7% responded. No difference was detected between infants after CVS compared with infants after AC regarding congenital malformations (7.2% versus 6.3%), neonatal morbidity (15.1% versus 15.9%), paediatric morbidity with clinical treatment (7.7% versus 6.3%) or outpatient treatment only (43.9% versus 40.3%) and evident function disturbance (2.0% versus 2.0%) or doubtful function disturbance (6.3% versus 6.8%). The number of infants with physical growth <10th centile for Dutch infants was equal (10.1%). Sub‐analysis for limb abnormalities or respiratory complications did not demonstrate differences between infants after CVS and AC. Only 10% of all congenital malformations were already known through routine post‐partum follow‐up. Conclusion An extensive long‐term survey could not demonstrate differences of health status between infants after prenatal diagnosis by transcervical CVS and AC. Copyright © 2002 John Wiley & Sons, Ltd.