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Genomic microarrays: a technology overview
Author(s) -
Brady Paul D.,
Vermeesch Joris R.
Publication year - 2012
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2933
Subject(s) - dna microarray , computational biology , prenatal diagnosis , genetics , biology , comparative genomic hybridization , genomics , intellectual disability , genomic sequencing , genomic medicine , bioinformatics , medicine , genome , pregnancy , fetus , gene , gene expression
Genomic microarrays are now widely used diagnostically for the molecular karyotyping of patients with intellectual disability, congenital anomalies and autistic spectrum disorder and have more recently been applied for the detection of genomic imbalances in prenatal genetic diagnosis. We present an overview of the different arrays, protocols used and discuss methods of genomic array data analysis. © 2012 John Wiley & Sons, Ltd.

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