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Evaluation of placental syndecan‐1 expression in early pregnancy as a predictive fetal factor for pregnancy outcome
Author(s) -
Schmedt Anna,
Götte Martin,
Heinig Jörg,
Kiesel Ludwig,
Klockenbusch Walter,
Steinhard Johannes
Publication year - 2012
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2908
Subject(s) - placenta , chorionic villi , chorionic villus sampling , pregnancy , fetus , obstetrics , immunostaining , andrology , immunohistochemistry , biology , medicine , prenatal diagnosis , genetics
Objective Early expression of syndecan‐1, a regulator of growth factor and chemokine function, in animal and human abortuses or placenta at delivery suggests a potential role during embryonic development. The aim of this study was to examine the correlation between early placental syndecan expression and fetal outcome in ongoing pregnancies. Methods Prospective immunohistochemical analysis of 203 chorionic villus sampling specimens obtained during a 4‐year period (2001–2004). The chorionic villi were processed for paraffin‐embedded immunohistochemistry. Scores of intensity of syndecan‐1 expression in chorionic villi were correlated with maternal cofactors and pregnancy outcome. Results Syndecan‐1 immunostaining was significantly related to villus size, maternal tobacco use, and fetal biometry at ultrasonography. After correcting the above confounders, scores of syndecan‐1 expression correlated with preterm birth and low birth weight. Conclusions Placental syndecan‐1 expression is associated with premature birth and fetal growth. © 2012 John Wiley & Sons, Ltd.