Premium
Aortic isthmus blood flow in fetuses of diabetic mothers
Author(s) -
Zielinsky Paulo,
Frajndlich Renato,
Nicoloso Luiz Henrique,
Manica João Luiz Langer,
Piccoli Antonio Luiz,
Morais Marina Resener,
Bender Luciano,
Silva Júlia,
Pizzato Patrícia,
Naujorks Alexandre
Publication year - 2011
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2859
Subject(s) - fetus , medicine , diabetes mellitus , gestational diabetes , gestational age , analysis of variance , pregnancy , in utero , obstetrics , endocrinology , cardiology , gestation , biology , genetics
Objective To test the hypothesis that the aortic isthmus flow index (IFI) is lower in fetuses of diabetic mothers than in fetuses of nondiabetic mothers. Study Design We performed a cross‐sectional observational study to assess the IFI in fetuses, with ( n = 13) and without ( n = 37) myocardial hypertrophy, of mothers with diabetes mellitus and in fetuses of nondiabetic mothers ( n = 23). Analysis of variance and Tukey test were used to assess differences among the groups. Results There were no differences in maternal or gestational age among the groups. In fetuses of diabetic mothers, the mean IFI in fetuses with myocardial hypertrophy was 1.19 ± 0.06, and in fetuses without it was 1.18 ± 0.09. The mean IFI in fetuses of nondiabetic mothers was 1.32 ± 0.07 ( P < 0.001). Conclusions The IFI in fetuses of diabetic mothers is lower than in fetuses of nondiabetic mothers, possibly as a result of a decreased left ventricular compliance. Copyright © 2011 John Wiley & Sons, Ltd.