Premium
Uterine artery Doppler and biochemical markers (PAPP‐A, PlGF, sFlt‐1, P‐selectin, NGAL) at 11 + 0 to 13 + 6 weeks in the prediction of late (>34 weeks) pre‐eclampsia
Author(s) -
Youssef Aly,
Righetti Francesca,
Morano Danila,
Rizzo Nicola,
Farina Antonio
Publication year - 2011
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2848
Subject(s) - placental growth factor , medicine , uterine artery , soluble fms like tyrosine kinase 1 , eclampsia , lipocalin , gestation , pregnancy , endocrinology , obstetrics , biology , vascular endothelial growth factor , vegf receptors , genetics
Objective To determine the performance of screening for late pre‐eclampsia (PE) by maternal characteristics, uterine artery Doppler and a set of biochemical markers at 11 + 0 to 13 + 6 weeks' gestation. Methods Prospectively enrolled women at 11 + 0 to 13 + 6 weeks. Maternal characteristics, highest UtA pulsatility index and serum placental biomarkers including pregnancy‐associated plasma protein‐A, placental growth factor, soluble fms‐like tyrosine kinase 1, P‐selectin and neutrophil gelatinase‐associated lipocalin were recorded. Results The rate of PE was 2.5% (13/528). Four (0.8%) had severe PE. A combined screening model that included placental growth factor, soluble fms‐like tyrosine kinase 1 and neutrophil gelatinase‐associated lipocalin could detect 77% of PE at a 10% false‐positive rate. Mean risk for mild PE was 8.8% ± 6.4, mean risk for severe PE was 38.6% ± 4.3. Mean risk for controls was 2% ± 4.1. Conclusion This combination of maternal biochemical variables in the first trimester can detect a consistent number of late PE. Further studies on a new and independent series of data could confirm the presented results. Copyright © 2011 John Wiley & Sons, Ltd.