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Fetal stress hormone changes during intrauterine transfusions
Author(s) -
Adama van Scheltema P. N.,
Pasman S. A.,
Wolterbeek R.,
Deprest J. A.,
Oepkes D.,
De Buck F.,
Van de Velde M.,
Vandenbussche F. P. H. A.
Publication year - 2011
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2745
Subject(s) - fetus , medicine , hormone , obstetrics , pregnancy , endocrinology , biology , genetics
Objective To document fetal stress hormone and Doppler changes after intrauterine transfusions (IUTs) in either the intrahepatic portion of the umbilical vein (IHV) or the placental cord insertion (PCI). Method Pregnant women scheduled for IUT for fetal anemia ( N = 25) were included prospectively. Cortisol, β‐endorphin and noradrenalin concentrations in fetal plasma and middle cerebral artery pulsatility index before and after transfusion were compared. Transfusions were performed through the (IHV), thus puncturing the fetus, or at the PCI. Results There were no measurable differences between the transfusion sites. Conclusion In anemic fetuses undergoing transfusion, Doppler changes and fetal stress hormone changes were unrelated to the site of needle insertion. Copyright © 2011 John Wiley & Sons, Ltd.