Premium
Hemangioma in the newborn: increased incidence after chorionic villus sampling
Author(s) -
Bauland Constantijn G.,
Smit Jeroen M.,
Bartelink Lidewij R.,
Zondervan Hans A.,
Spauwen Paul H. M.
Publication year - 2010
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2562
Subject(s) - amniocentesis , medicine , chorionic villus sampling , triple test , obstetrics , physical examination , incidence (geometry) , hemangioma , prenatal diagnosis , pregnancy , gynecology , odds ratio , surgery , fetus , pathology , genetics , physics , optics , biology
Objectives This study was designed to compare the effects of transcervical chorionic villus sampling (CVS) and amniocentesis on the prevalence of hemangiomas of infancy. Methods This is a cohort study of 250 consecutive assessable transabdominal amniocentesis procedures and 250 consecutive assessable transcervical CVS procedures performed between January and September 2002. Parents were asked to fill out a questionnaire regarding the presence of any type of skin lesions. Based on the responses to the questionnaire, children were invited to undergo a physical examination to confirm hemangiomas. Results Questionnaires were returned in 78% of the CVS group (195/250) and in 72% of the amniocentesis group (180/250). Based on the responses in the questionnaire, 78 children in the CVS group and 42 in the amniocentesis group underwent a physical examination. One or more hemangiomas were present in 53 of 195 (27.2%) children in the CVS group versus 17 of 180 (9.4%) children in the amniocentesis group (odds ratio 3.6, 95% CI: 2.0–6.5). There was no difference in congenital abnormalities between the two groups. Conclusion Transcervical CVS is associated with a significantly increased prevalence of hemangiomas compared with amniocentesis. The clinical features of these hemangiomas do not differ from natural hemangiomas and complications of these hemangiomas are very rare. Copyright © 2010 John Wiley & Sons, Ltd.