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Is maternal renal disease a cause of elevated free β‐hCG in first trimester aneuploidy screening?
Author(s) -
Spencer Kevin,
Enofe Osasumwen,
Cowans Nicholas J.,
Stamatopoulou Anastasia
Publication year - 2009
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2347
Subject(s) - renal function , aneuploidy , medicine , trisomy , creatinine , pregnancy , endocrinology , down syndrome , obstetrics , cohort , urology , gynecology , biology , chromosome , biochemistry , genetics , psychiatry , gene
Abstract Objective To asses whether supra elevated levels of maternal serum free beta hCG in the first trimester are associated with impaired renal function. Method A cohort of 553 women with maternal serum free β‐hCG greater than 5 multiple of median (MoM) with a single euploid fetus was matched with a control of the same maternal age (+/−1 year), ethnic origin and with a free β‐hCG within the range 0.50–1.50 MoM. Screening samples were analysed for serum creatinine and estimated glomerular filtration rate was calculated. Renal function in the two groups was compared. The database was examined to find outcomes registered as known renal disease amongst the high free β‐hCG group. Results In the group with a supra elevated free β‐hCG MoM there was a significant reduction in estimated glomerular filtration rate (eGFR) (122.85, 95% CI 120.43–124.74 vs 118.80, 95% CI 114.90–121.59; p = 0.009) suggesting a small but increased risk of renal disease. Conclusions The presence of renal disease should also be considered as one potential cause of supra elevated levels of free β‐hCG in addition to the possibility of paternally derived triploidy and trisomy 21. Copyright © 2009 John Wiley & Sons, Ltd.