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Screening options for Down syndrome: how women choose in real clinical setting
Author(s) -
Lo T. K.,
Lai F. K.,
Leung W. C.,
Lau W. L.,
Ng L. S.,
Wong W. C.,
Tam S. S.,
Yee Y. C.,
Choi H.,
Lam H. S. W.,
Sham A. S. Y.,
Tang L. C. H.,
Chin R. K. H.
Publication year - 2009
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2292
Subject(s) - test (biology) , medicine , socioeconomic status , preference , multinomial logistic regression , pregnancy , demography , obstetrics , advanced maternal age , family history , ethnic group , gynecology , population , environmental health , paleontology , fetus , genetics , radiology , sociology , biology , machine learning , computer science , anthropology , economics , microeconomics
Objective To study pregnant women's preference among various screening options for Down syndrome (DS) in routine clinical setting, and its potential association with women's demographic characteristics. Methods Women aged 35 years and older carrying singleton pregnancy were offered a variety of screening tests for DS before 14 weeks of gestation. Their preference was confirmed by the test they actually underwent. The association between women's choice of test and a number of demographic characteristics was studied using multinomial regression. Results Among 1967 eligible women, 619 opted for first‐trimester screening test (FTS), 924 for partial integrated test (PIT), and 424 for full integrated test (FIT). Nulliparous women and working mothers were more likely to choose FTS and FIT. Women with history of subfertility were more likely to choose FIT. Women with family history of chromosomal abnormalities were more likely to choose FTS. The choice of screening test could be predicted for 49.9% of women using four demographic characteristics. Conclusions Among older women of predominantly Chinese ethnicity, integrated test is a favorite alternative to FTS. Their choice of DS screening test can be predicted by their obstetric and socioeconomic characteristics. Many women show willingness to pay for a test with a lower false‐positive rate. Copyright © 2009 John Wiley & Sons, Ltd.