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Performance of first‐trimester combined screening for trisomy 13 and 18 with the double test taken at a gestational age of 8 + 0 to 13 + 6
Author(s) -
Kirkegaard Ida,
Petersen Olav Bjørn,
Uldbjerg Niels,
Tørring Niels
Publication year - 2009
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2254
Subject(s) - trisomy , medicine , first trimester , nuchal translucency , gestational age , obstetrics , gynecology , down syndrome , aneuploidy , pregnancy , gestation , biology , chromosome , genetics , psychiatry , gene
Objective To evaluate the performance of the combined test for first‐trimester screening for trisomy 18 and 13, when the double test is scheduled weeks before the nuchal translucency scanning. Methods The study included all 40 cases of trisomy 18 and 13 from April 2004 to October 2008 in a screening programme, where the double test was measured in gestational weeks 8 + 0 to 13 + 6 and the nuchal translucency in weeks 11 + 2 to 13 + 6. Results Twenty‐eight among the 40 cases had complete information on all variables in the first‐trimester screening test. Among 19 cases having the double test taken before 10 + 0 weeks, 10 cases were detected (detection rate (DR) = 53%) and among 9 cases having the double test taken after 10 + 0 weeks, 6 cases were detected (DR 67%). There was no significant difference in the DRs ( p = 0.48). A total of 29 cases were detected at the first‐trimester screening, resulting in an overall DR for trisomy 18 and 13 at 73%. Conclusion This study showed no significant differences in the trisomy 18/13 DRs when grouped according to having the double test taken before or after 10 + 0 weeks. The DR was 73% at the first‐trimester screening. Copyright © 2009 John Wiley & Sons, Ltd.