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Fetal dilated cardiomyopathy: an unsuspected presentation of methylmalonic aciduria and hyperhomocystinuria, cblC type
Author(s) -
De Bie Isabelle,
Nizard Sonia Dal Pozzo,
Mitchell Grant A.
Publication year - 2009
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.2218
Subject(s) - methylmalonic aciduria , medicine , fetus , dilated cardiomyopathy , presentation (obstetrics) , cardiomyopathy , pathology , cobalamin , cardiology , pregnancy , biology , genetics , obstetrics , heart failure , vitamin b12
Objective To report the prenatal presentation with dilated cardiomyopathy of methylmalonic aciduria and homocystinuria, cblC type [cobalamin C (cblC) deficiency] (MIM 277400). Method We describe a boy with cblC deficiency who presented prenatally with fetal ultrasound findings of dilated cardiomyopathy and growth restriction. Results Dilated cardiomyopathy and growth retardation were detected in the third trimester of an initially uncomplicated pregnancy. Investigations were negative for chromosomal and other known causes. Growth restriction persisted but fetal heart function improved. Postnatal biochemical evaluation revealed combined methylmalonic acidemia and homocystinemia. Molecular investigations confirmed cblC deficiency. Initiation of treatment was followed by rapid clinical improvement. Conclusion Prenatal dilated cardiomyopathy can be the presenting sign of cblC deficiency. Inborn errors of metabolism should be considered in the investigation of prenatally diagnosed dilated cardiomyopathy in view of the possible impact on treatment and future reproductive options, in some of these conditions. Copyright © 2009 John Wiley & Sons, Ltd.