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Early amniocentesis: A clinical review
Author(s) -
Wilson R. Douglas
Publication year - 1995
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970151307
Subject(s) - amniocentesis , chorionic villus sampling , medicine , obstetrics , gestation , prenatal diagnosis , pregnancy , first trimester , gynecology , fetus , biology , genetics
Early amniocentesis at less than 14 weeks gestation is becoming more common in prenatal diagnosis populations. Randomized studies are minimal and have not had the power to determine the accuracy and safety of the procedure compared to chorionic villus sampling or mid‐trimester amniocentesis. Procedures at 11 +0 ‐12 +6 weeks should be considered experimental. This clinical review considers the ethics, embryology, and clinical experience (cytogenetics, AFP, AChE, procedure and cytogenetic failures, spontaneous and therapeutic pregnancy losses, congenital anomalies) of early amniocentesis.