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Fetal urinary insulin‐like growth factor I and binding protein 3 in bilateral obstructive uropathies
Author(s) -
Bussieres L.,
Laborde K.,
Souberbielle J. C.,
Muller F.,
Dommergues M.,
Sachs C.
Publication year - 1995
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970151110
Subject(s) - obstructive uropathy , medicine , oligohydramnios , urinary system , renal function , urology , creatinine , fetus , endocrinology , insulin like growth factor , pregnancy , growth factor , biology , receptor , genetics
Fetal urinary concentrations of insulin‐like growth factor I (UIGF‐I) and binding protein 3 (UIGFBP‐3) were determined in patients with prenatal diagnosis of bilateral obstructive uropathy. Patients were retrospectively assigned to three groups, on the basis of outcome: group 1, termination of pregnancies ( n = 11) with sonographic evidence of severe oligohydramnios or renal dysplasia, confirmed at histological examination; group 2, patients ( n = 10) with postnatal plasma creatinine > 50 μmol/1 at the age of 1 year (1 yr‐pCreat); and group 3, patients ( n = 16) with 1 yr‐pCreat ≤ μmol/1. The results show a significant increase in UIGF‐I and UIGFBP‐3 in groups 1 (18 159 ± 9083 pg/ml; 2657 ± 669 ng/ml) and 2 (1574 ± 847 pg/ml; 176 ± 50 ng/ml) in comparison with group 3 (35 ± 6 pg/ml; 21 ± 2 ng/ml). UIGF‐I and UIGFBP‐3 were significantly correlated with postnatal plasma creatinine, and were both sensitive (90 per cent; 80 per cent) and specific (88 per cent; 88 per cent) for prediction of elevated 1 yr‐pCreat (>50 μmol/1). Fetal urinary IGF‐I and IGFBP‐3 are increased in severe fetal bilateral obstructive uropathy, possibly reflecting tubular dysfunction or/and increased synthesis consequent upon fetal kidney injury. Their predictive value for postnatal renal function needs further assessment.