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Methods for the transcervical collection of fetal cells during the first trimester of pregnancy
Author(s) -
Rodeck Charles,
Tutschek Boris,
Sherlock Jon,
Kingdom John
Publication year - 1995
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970151008
Subject(s) - medicine , fetus , pregnancy , chorionic villus sampling , gynecology , obstetrics , first trimester , mucus , andrology , biology , ecology , genetics
Before termination of pregnancy, four techniques for retrieving fetal cells transcervically were investigated: uterine lavage, endocervical lavage, cytobrush and mucus aspiration. The yield of fetal cells in these samples was studied and found to be somewhat better after uterine lavage. A preliminary assessment of the safety of mucus aspiration was carried out before transcervical chorionic villus sampling (CVS) in continuing pregnancies. No difference in outcome to a control group having only CVS was found.