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Neutrophil and monocyte β2‐integrin expression in trisomic fetuses
Author(s) -
Makrydimas G.,
Thilaganathan B.,
Plachouras N.,
Nicolaides K. H.
Publication year - 1995
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970150405
Subject(s) - trisomy , fetus , flow cytometry , aneuploidy , pathogenesis , monocyte , biology , down syndrome , andrology , integrin , immunology , pathology , medicine , pregnancy , genetics , cell , chromosome , gene
Abstract Flow cytometry was used to measure neutrophil and monocyte β2‐integrin expression in fetuses with trisomy 18 ( n =7) and trisomy 21 ( n =7) at 20–25 weeks' gestation. The values were compared with those of 112 chromosomally normal fetuses. There were no significant differences in β2‐integrin expression between normal and aneuploid fetuses. These findings demonstrate that in trisomies 21 and 18, alteration in β2‐integrin expression is unlikely to contribute to the pathogenesis of immunological deficiencies that have been observed in these aneuploidies both prenatally and postnatally.