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An increased incidence of haemangiomas in infants born following chorionic villus sampling (CVS)
Author(s) -
Burton Barbara K.,
Schulz Charlene J.,
Angle Brad,
Burd Laurence I.
Publication year - 1995
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970150302
Subject(s) - amniocentesis , chorionic villus sampling , medicine , incidence (geometry) , obstetrics , prenatal diagnosis , gestational age , population , pregnancy , triple test , gestation , gynecology , fetus , genetics , physics , environmental health , optics , biology
The incidence of haemangiomas was ascertained by questionnaire in infants born to 578 consecutive CVS patients and 445 consecutive mid‐trimester amniocentesis patients seen at a single institution between 1 January 1989 and 31 May 1991. The incidence of 7·4 per cent reported in the amniocentesis group was comparable to previous estimates of the incidence of haemangiomas in the general population. In contrast, a 21·1 per cent incidence, three‐fold higher than that observed in the amniocentesis group, was observed among CVS‐exposed infants ( P <0·001). This increased incidence was largely confined to patients undergoing a transcervical procedure. No correlation was observed between the incidence of haemangiomas and gestational age at sampling, sample size, number of sampling attempts, or a history of bleeding following the procedure.