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Accuracy of amniotic fluid testing before 21 weeks' gestation in prenatal diagnosis of congenital cytomegalovirus infection
Author(s) -
Donner Catherine,
Liesnard Corinne,
Brancart Françoise,
Rodesch Frederic
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970141108
Subject(s) - amniocentesis , gestation , medicine , obstetrics , amniotic fluid , cytomegalovirus , prenatal diagnosis , pregnancy , in utero , fetus , gynecology , herpesviridae , viral disease , immunology , biology , virus , genetics
Cytomegalovirus (CMV) is the most common cause of intrauterine infection. Recent publications show amniocentesis to have an 81–100 per cent sensitivity in antenatal diagnosis after 21 weeks' gestation. Testing before 21 weeks' gestation is less well documented. We performed 36 amniocenteses between 14 and 20 weeks' gestation. The sensitivity was 45 per cent and the specificity 100 per cent. Implications and possible causes of this low sensitivity are discussed.