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Successful outcome of pregnancy after treatment of maternal anti‐ro (SSA) antibodies with immunosuppressive therapy and plasmapheresis
Author(s) -
Van Der Leij J. N.,
Visser G. H. A.,
BinkBoelkens M. Th. E.,
Meilof J. F.,
Kallenberg C. G. M.
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970141019
Subject(s) - plasmapheresis , pregnancy , medicine , azathioprine , prednisolone , antibody , fetus , obstetrics , pediatrics , immunology , disease , genetics , biology
In this short communication we describe a patient with anti‐SSA and anti‐SSB antibodies whose first child died of congenital complete heart block (CCHB). During her second pregnancy she was treated with prednisolone, azathioprine, and plasmapheresis, and levels of anti‐SSA and anti‐SSB antibodies fell significantly. The pregnancy evolved uneventfully and resulted in the birth of an unaffected male infant. This is the fourth reported case of a successful outcome of pregnancy after treatment with immunosuppressive drugs in a woman with a significant risk of recurrence of CCHB.