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Tumour‐associated antigens in maternal and fetal blood
Author(s) -
Hohlfeld Patrick,
Dang ThiTan,
Nahoul K.,
Daffos Fernand,
Forestier François
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970141003
Subject(s) - fetus , antigen , medicine , pregnancy , obstetrics , immunology , biology , genetics
Normal levels of cancer‐associated antigen (CA) 19‐9, neurone‐specific enolase (NSE), cancer‐associated antigen (CA) 125, and mucin‐like carcinoma‐associated antigen (MCA) during pregnancy were determined in 87 mothers and fetuses, using a solid‐phase sandwich enzyme immunoassay. CA 19‐9 concentrations were higher in the fetuses, whereas the other three tumour‐associated antigen levels were higher in the mothers. Only fetal NSE and MCA levels were positively correlated with those in maternal serum. Contrary to adult samples, no difference was demonstrated between male and female fetal levels of CA 125. MCA was the only maternal marker that increased significantly with gestational age between 20 and 34 weeks' pregnancy.