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Minute chromatin structures in cells of amniotic fluid—an interpretative dilemma
Author(s) -
Wang Hungshu,
Bellinger Judith L.,
Brierley Kathleen,
Dawson Laura E.,
Goldsmith Claire L.,
Hunter Alasdair G. W.
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970140917
Subject(s) - amniotic fluid , cord blood , umbilical cord , fetus , medicine , obstetrics , pregnancy , cord , girl , peripheral blood , chromosome , andrology , biology , surgery , anatomy , genetics , gene
Single copies of tiny chromosome fragments, appearing either as single or as double minutes, were observed in a high frequency in amniotic fluid cultures of five mothers who underwent prenatal testing because of advanced age. In four cases, the minutes had arisen de novo . The minutes were later confirmed in fetal skin following termination of pregnancy in one case; in another, in cord blood following the birth of a normal boy; and in the third, in peripheral blood of a normal 3‐year‐old girl. In the fourth case, the minutes were not confirmed in cord blood following the birth of a normal boy. A follow‐up chromosome study of the baby boy in the fifth case was not possible but the minutes were maternally transmitted.