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Prenatally diagnosed non‐immune hydrops caused by congenital transient leukaemia
Author(s) -
Donnenfeld Alan E.,
Scott Steven C.,
HenselderKimmel Marie,
Dampier Carlton D.
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970140812
Subject(s) - ctl* , fetus , medicine , hydrops fetalis , bone marrow , pathology , immunology , immune system , pregnancy , biology , cd8 , genetics
Congenital transient leukaemia (CTL) is a haematological disorder characterized by proliferation of myeloblasts within the bone marrow and peripheral blood of affected newborns. Infants with Down syndrome are most frequently affected and although the disorder can result in fetal death due to hydrops, it typically resolves spontaneously after birth. We present a case of prenatally diagnosed fetal hydrops accompanied by splenomegaly and an enlarged, echogenic liver in a fetus identified with CTL after birth.