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Chorionic villus sampling utilization following reports of a possible association with fetal limb defects
Author(s) -
Cutillo Denise M.,
Hammond Elizabeth A.,
Reeser Suzanne L.,
Kershner Melissa A.,
Lukin Barbara,
Godmilow Lynn,
Donnenfeld Alan E.
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970140502
Subject(s) - chorionic villus sampling , amniocentesis , medicine , prenatal diagnosis , obstetrics , genetic counseling , gestation , pregnancy , population , fetus , chorionic villi , gynecology , advanced maternal age , pediatrics , genetics , environmental health , biology
Prenatal diagnosis choices were reviewed in 473 women who presented for genetic counselling prior to 11 weeks' gestation for the indication of advanced maternal age. Group A consisted of 336 patients who were unaware of a possible association between chorionic villus sampling (CVS) and limb defects. Group B consisted of 137 patients who were provided this information. Fifty‐one per cent of patients in group A and 45 per cent of patients in group B chose CVS. This difference was not significant by χ 2 analysis ( P = 0·7). Patterns of prenatal diagnosis procedure utilization from 1987 to 1992 revealed a significant reduction in CVS utilization accompanied by a corresponding increase in amniocentesis after the association between CVS and limb defects was publicized. Referrals for CVS counselling also significantly declined. However, acceptance rates did not change for those patients who received genetic counselling. First‐trimester genetic counselling, including a discussion regarding a possible association between CVS and limb defects, helps patients make informed decisions concerning prenatal diagnosis options, and, in our population, resulted in no change in CVS acceptance rates.