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Human parvovirus B19 infection and unbalanced translocation in a case of hydrops fetalis
Author(s) -
Willekes Christine,
Roumen Frans J. M. E.,
van ElsackerNiele AnneMarie W.,
Weiland Harro T.,
VermeyKeers Christl,
van Krieken Johan H. J. M.,
de DieSmulders Christine E. M.,
Hamers Guus J. H.,
VaesPeters Gerrie P. M.
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970140307
Subject(s) - hydrops fetalis , parvovirus , chromosomal translocation , fetus , amniocentesis , biology , parvoviridae , prenatal diagnosis , serology , immunology , virology , obstetrics , pregnancy , pathology , medicine , virus , antibody , genetics , gene
In a case of hydrops fetalis, serological examination showed a recent maternal human parvovirus B19 infection. Amniocentesis revealed a unique unbalanced translocation between chromosomes 3 and 11 of the fetus. The mother proved to have a balanced reciprocal translocation between chromosomes 3 and 11. A grossly macerated hydropic male fetus was delivered with a flat nose and low implanted deformed ears. Histopathological examination revealed nuclear inclusion bodies in fetal erythroid cells, confirming human parvovirus B19 infection. Parvovirus B19 DNA was demonstrated by in situ hybridization in the nuclei of heart muscle cells. Our finding of two different disorders in one case illustrates the importance of a complete evaluation of every case of hydrops fetalis, especially concerning counselling on the outcome of future pregnancies. The human parvovirus B19 infection will not recur due to the acquired immunity of the mother, whereas the balanced reciprocal translocation will endanger future pregnancies.