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A fetus with a parvovirus B19 infection and congenital anomalies
Author(s) -
Tiessen R. G.,
van ElsackerNiele A. M. W.,
VermeijKeers Chr.,
Oepkes D.,
van Roosmalen J.,
Gorsira M. C. B.
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970140305
Subject(s) - parvovirus , fetus , medicine , pathology , aborted fetus , prenatal diagnosis , pregnancy , biology , virology , virus , genetics
A fetus with multiple structural defects was seen at prenatal ultrasound examination. After termination of the pregnancy a bilateral cleft lip, alveolus, and palate; micrognathia; and webbed joints were seen. Fetal tissues showed indications of infection, intranuclear inclusion bodies, chronic stress, haemolysis, arterial wall damage, and profuse haemorrhage. Parvovirus B19 DNA was detected in fetal tissues by dot hybridization after polymerase chain reaction. The possibility of parvovirus B19 infection leading to congenital malformations is discussed.