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Transabdominal chorionic villus sampling and amniocentesis for prenatal diagnosis: 5 years' experience at a University Centre
Author(s) -
Palo Pertti,
Piiroinen Olli,
Honkonen Erkki,
Lakkala Taina,
Aula Pertti
Publication year - 1994
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970140302
Subject(s) - chorionic villus sampling , amniocentesis , medicine , prenatal diagnosis , obstetrics , gestation , chorionic villi , fetus , gynecology , pregnancy , biology , genetics
The fetal loss rates and fetal congenital birth defects in 821 transabdominal (TA) chorionic villus sampling (CVS) and 771 amniocentesis (AC) cases were evaluated from a 5‐year period (1987–1991) at the University Central Hospital of Turku. The parents were given the option of choosing between the two sampling procedures. CVS was performed, in most cases, at 11 weeks of gestation; and AC, at 15 weeks. The rate of total post‐procedure loss was 6·7 per cent in the CVS group and 4·4 per cent in the AC group ( p =0·08). The rate of spontaneous abortions was 1·9 per cent in the CVS group and 1·0 per cent in the AC group ( p =0·10). The number of birth defects was low in both study groups. No limb reduction cases were observed. Mosaicism was noted in 14 CVS cases and in five AC cases. We conclude that TA‐CVS is a safe and practical alternative to AC in prenatal fetal karyotyping.